Table 4.
Associations of Reported Barriers to Adherence by Regimen Complexity among People on Non-salvage Treatment
| Scheduling barriers | ART-induced barriers | Other barrier | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Forgot | Too busy | Something unexpected came up | Making me sick | Felt depressed and overwhelmed | Got confused with what to take | |
|
| ||||||
| OR (95%CI) | OR (95%CI) | OR (95%CI) | OR (95%CI) | OR (95%CI) | OR (95%CI) | |
| Dosing complexity | ||||||
| STR | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Single-dose MTR | 1.66(1.14, 2.42)** | 1.86(1.21, 2.88)** | 1.70(1.10, 2.63)* | 3.49(1.38, 8.79)** | 2.11(0.98, 4.54) | 4.26(0.93, 19.63) |
| Multi-dose MTR | 2.13(1.47, 3.08)*** | 2.46(1.61, 3.74)*** | 1.78(1.16, 2.74)** | 2.82(1.15, 6.92)* | 2.22(1.03, 4.82)* | 6.10(1.43, 26.13)* |
| P-value for Trend1 | <0.001 | <0.001 | 0.013 | 0.010 | 0.062 | 0.005 |
| Time-invariant covariates | ||||||
| CES-D | 1.01(1.00, 1.02)* | 1.00(0.99, 1.01) | 1.01(0.99, 1.02) | 1.01(0.98, 1.03) | 1.05(1.03, 1.07)*** | 1.01(0.98, 1.04) |
| Self-efficacy | 0.89(0.83, 0.95)*** | 0.86(0.80, 0.93)*** | 1.33(1.13, 1.56)** | 0.85(0.75, 0.96)* | 0.89(0.78, 1.00) | 0.99(0.83, 1.20) |
| Time-variant covariates | ||||||
| Time 0 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Time 1 | 0.84(0.66, 1.07) | 0.75(0.58, 0.98)* | 0.80(0.60, 1.05) | 0.72(0.45, 1.13) | 0.73(0.45, 1.21) | 0.62(0.32, 1.23) |
| Time 2 | 0.89(0.70, 1.13) | 0.81(0.62, 1.04) | 0.85(0.65, 1.10) | 0.56(0.34, 0.90)* | 0.77(0.46, 1.28) | 0.84(0.44, 1.64) |
| Side-effect | 1.23(1.07, 1.41)** | 0.86(0.80, 0.93)* | 1.3(1.13, 1.56)*** | 2.52(2.01, 3.17)*** | 1.52(1.15, 2.01)** | 1.85(1.33, 2.57)*** |
1
Testing gradient or curvilinear relationship between dosing complexity and barriers;
*
p<0.05,
**
p<0.01,
***
p<0.001;
STR: single-tablet regimen; MTR: multi-tablet regimen; CES-D: Center for Epidemiologic Studies Depression Scale.