Figure 3. Effect of 16 on airway hyperresponsiveness.
Specific airway resistance (sRAW) to increasing doses of methacholine measured by DSI's Buxco® FinePointe non-invasive airway mechanics instrument. (A) BALB/c mice were administered 40 mg/kg of 16 single i.p. injection 40 minutes prior to analysis; (B) administration of 16 at 40 mg/kg i.p. injections daily for 5 days. Data represent mean ± SEM from 4–7 mice in each group. * indicates p < 0.05 significance compared to vehicle-treated mice.