Table 4.

Drug concentrations in the serum and CSF of the conventional group

Time (hours)	Norvancomycin (x ± SD)(n)(range)
	Serum	Cerebrospinal fluid
Prior to administration	0	0
1	55.52 ± 26.04(8) (8.79–91.84)	15.78 ± 8.63(7) (4.03–27.05)
2	33.33 ± 23.52(11) (6.07–67.21)	16.14 ± 9.57(11) (3.03–26.34)
3	22.35 ± 20.37(10) (3.38–59.13)	16.31 ± 11.15(9) (3.48–37.95)
4	15.68 ± 14.77(5) (3.44–39.65)	15.18 ± 16.88(6) (3.37–48.66)
6	12.07 ± 7.50(5) (6.10–24.99)	10.00 ± 7.88(4) (2.80–21.21)
12	10.62 ± 10.33(10) (2.15–36.88)	8.32 ± 5.16(12) (2.68–19.75)
13	49.73 ± 35.31(5) (4.77–102.48)	7.62 ± 3.78(3) (4.49–11.81)
14	17.22 ± 6.52(3) (11.93–24.50)	8.32 ± 6.34(3) (3.19–15.41)
24	8.21 ± 6.04(5) (2.10–17.13)	6.12 ± 2.34(5) (3.15–9.24)