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Cell type-specific effects of NMDAR-PAMs. (a) GNE-8324 has no effect on NMDAR EPSPs recorded from CA1 pyramidal neurons in acute brain slices. (b) In contrast, GNE-6901 showed robust potentiation on NMDAR EPSPs under the same condition. (c, d) Robust potentiation of both GNE-8324 and GNE-6901 on NMDAR EPSCs recorded in the inhibitory neurons in the hippocampus. Modified from [28].
