Table 1.
Patient characteristics and univariate relationships
| Total population N = 216 |
No EF decline N = 185 |
EF decline >10 % N = 27 |
p value | |
|---|---|---|---|---|
| Type of cancer | ||||
| Breast | 82 (38 %) | 71 (38 %) | 11 (41 %) | 0.001 |
| Sarcoma | 91 (42 %) | 85 (46 %) | 6 (22 %) | |
| Leukemia | 42 (19 %) | 33 (18 %) | 9 (33 %) | |
| Lymphoma | 1 (0.5 %) | 0 | 1 (3.7 %) | |
| Age (years) | 39 (2–45) | 39 (22.5–44.5) | 39 (27–45) | 0.59 |
| Gender—female | 139 (65 %) | 119 (64 %) | 20 (74 %) | 0.47 |
| Comorbid conditions | ||||
| Diabetes | 54 (25 %) | 47 (25 %) | 7 (26 %) | 1 |
| Hypertension | 75 (35 %) | 59 (32 %) | 16 (59 %) | 0.008 |
| Hyperlipidemia | 47 (22 %) | 35 (19 %) | 12 (44 %) | 0.005 |
| Coronary artery disease | 16 (7.4 %) | 11 (6 %) | 5 (18 %) | 0.03 |
| Radiation treatment | 100 (46 %) | 89 (48 %) | 11 (40 %) | 0.68 |
| Smoking | 57 (26 %) | 51 (28 %) | 6 (22 %) | 0.81 |
| Hx of systolic/diastolic heart failure (prior to chemo) |
25 (12 %) | 13 (7 %) | 12 (44 %) | 0.001 |
| Imaging modality | ||||
| TTE | 96 (44 %) | 85 (46 %) | 11 (41 %) | |
| MUGA | 118 (55 %) | 104 (56 %) | 14 (52 %) | 0.028 |
| Stress MIBI | 1 (0.5 %) | 0 | 1 (3.7 %) | |
| TEE | 1 (0.5 %) | 0 | 1 (3.7 %) | |
| Baseline imaging | ||||
| Median EF (%) | 60 (58–63) | 60 (59–63) | 60 (56–61) | 1 |