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. Author manuscript; available in PMC: 2017 Jan 22.
Published in final edited form as: Cell Rep. 2017 Jan 3;18(1):174–184. doi: 10.1016/j.celrep.2016.12.027

Figure 5. RhoGAPp190 but not Pebble significantly enhances crossing defects in the FraΔC background.

Figure 5

(A) Quantification of EW midline crossing defects in the FraΔC screening background. Heterozygosity for RhoGAPp190 does not show a significant enhancement in crossing defects, however, RhoGAPp190 nulls do strongly enhance these defects (81%). pebble heterozygotes significantly suppressed these defects (10%). In addition, heterozygosity for rho1 or expression of a Rho1 dominant negative also suppresses the FraΔC phenotype. Data are represented as mean+SEM. n, number of embryos scored for each genotype. Significance was assessed by multiple comparisons using ANOVA (****p<0.0001, ***p<0.001, **p<0.01, *p<0.05). (B) Model of functional responses of Sema-1a reverse signaling through its downstream effectors.