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. 2017 Jan;6(1):46–56. doi: 10.21037/tp.2016.07.04

Figure 1.

Figure 1

The critical region for PWS on chromosome 15, with the main genes indicated. MKRN3 (or ZNF127) is a zinc finger protein, expressed only from the paternal chromosome; MAGEL2 is expressed only from the paternal chromosome mainly in the brain; NECDIN encodes a DNA binding protein; C15ORF2 is the open reading frame of the SNURF/SNRPN gene; MAGEL2, NDN and MKRN3 are all small intronless genes. Black lines and light blue ovals between BP2 and BP3 indicate imprinted genes in PWS, Black lines between BP1 and BP2 indicate non-imprinted genes and the 2 yellow circles are the maternally imprinted genes in Angelman syndrome. Exons 1-10 are within SNRPN; snoRNAs are here depicted pictorially. IPW, an RNA transcript lies within the snoRNA region, does not encode a protein but is paternally expressed only; SNORD116 also lies within the snoRNA region and is paternally expressed only. BP, breakpoint; Cen, centromere; tel, telomere.