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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Alcohol. 2016 Nov 10;58:107–125. doi: 10.1016/j.alcohol.2016.07.011

Fig. 4. Correlations between 3α,5α-THP levels and ethanol intake in individual BXD strains.

Fig. 4

Mice from each genotype received four cycles of chronic intermittent ethanol (CIE) vapor exposure (CIE group) or air exposure (CTL group) (16 h/day × 4 days, followed by 72-h withdrawal), alternated with 5-day drinking test cycles using a two-bottle (15% v/v ethanol vs. water) limited access (2 h/day) drinking model. Blood samples for 3α,5α-THP assay were collected 72 h after a fifth CIE or air exposure cycle. 3α,5α-THP levels are expressed as pg/mL and are reported for each individual mouse. Average ethanol intake (g/kg) refers to ethanol intake during Test 4 of the two-bottle choice test and is reported for each mouse. (A) Spearman r = –0.26, p = 0.001, n = 152. (B) Spearman r = –0.32, p < 0.0001, n = 167. (C) Spearman r = – 0.51, p < 0.0001, n = 85. (D) Spearman r = –0.38, p = 0.0001, n = 93. (E) Spearman r = –0.06, p = 0.61, n = 67. (F) Spearman r = –0.15, p = 0.19, n = 74.