Figure 6.

(R)-SAL and (S)-SAL stereoisomers showed a morphine-like interaction with the binding site of the μ-opioid receptor. Molecular docking analyses of morphine, (R)-SAL and (S)-SAL on the coordinates of the crystallized mouse μ-opioid receptor were performed. (A) Chemical structure of the molecules studied: morphine, (R)-SAL and (S)-SAL. Hydroxyl groups are represented in red and amino groups are represented in blue. (B–D) Best docking fits of the three studied molecules on the binding site of the μ-opioid receptor. The molecular surface of each molecule and the receptor is represented. A dotted line highlights the main interactions of the ligands with the binding site of the μ-opioid receptor.