Table 4.
A GeneGO (MetaCore) enrichment analysis was performed on 45 genes found enriched in our microarray, in the ABA-ISH and in the B* database, supplemented with genes which had previously been found to be positive in the parvafox nucleus (Girard et al., 2011).
| Rank | GO Processes | Total | P value | Min FDR | In Data | Network objects |
|---|---|---|---|---|---|---|
| 1 | Synaptic transmission | 826 | 3.628E-14 | 3.813E-11 | 17 | KCNAB3, Ionotropic glutamate receptor, NEFL, Cerebellin 1, Kainate receptor, Kv1.2, GluR5, HCN2, VAMP1, Kv3.1, Galpha(i)-specific amine GPCRs, GLyRA3, GlyRA1, Galpha(q)-specific peptide GPCRs, PLC-beta, HCN |
| 2 | Neuropeptide signaling pathway | 138 | 2.343E-12 | 1.231E-09 | 10 | Galpha(s)-specific CRF GPCRs, PACAP, Enkephalin A, GlyRA2, Neurexophilin 4, GlyRA1, Galpha(q)-specific peptide GPCRs, Neuropeptide S receptor, CRHR1 |
| 3 | Regulation of inhibitory postsynaptic membrane potential | 24 | 2.331E-11 | 8.165E-09 | 6 | Ionotropic glutamate receptor, Kainate receptor, GluR5, Galpha(i)-specific amine GPCRs, GlyRA1 |
| 4 | Regulation of membrane potential | 413 | 8.292E-11 | 2.179E-08 | 8 | Ionotropic glutamate receptor, Kainate receptor, GluR5, HCN2, GlyRA1, Galpha(q)-specific peptide GPCRs, HCN |
| 5 | Behavioral response to pain | 30 | 1.352E-10 | 2.842E-08 | 6 | Ionotropic glutamate receptor, Kainate receptor, Galpha(s)-specific CRF GPCRs, GluR5, Galpha(q)-specific peptide GPCRs, CRHR1 |
| 6 | Negative regulation of voltage-gated calcium channel activity | 6 | 6.228E-10 | 1.091E-07 | 4 | Galpha(s)-specific CRF GPCRs, Dopamine D2 receptor, Galpha(i)-specific amine GPCRs, CRHR1 |
| 7 | Negative regulation of synaptic transmission, glutamatergic | 19 | 1.140E-09 | 1.712E-07 | 5 | Ionotropic glutamate receptor, Kainate receptor, GluR5, Dopamine D2 receptor, Galpha(i)-specific amine GPCRs |
| 8 | Startle response | 41 | 4.127E-09 | 5.422E-07 | 5 | Enkephalin A, Dopamine D2 receptor, Galpha(i)-specific amine GPCRs, GlyRA1 |
| 9 | Regulation of JNK cascade | 178 | 7.792E-09 | 9.099E-07 | 5 | Ionotropic glutamate receptor, Kainate receptor, Ephrin-B receptors, Galpha(q)-specific peptide GPCRs, Ephrin-B receptor 1 |
| 10 | Ion transport | 1408 | 1.008E-08 | 1.059E-06 | 14 | KCNAB3, Ionotropic glutamate receptor, Kainate receptor, Kv1.2, GluR5, GlyRA2, HCN2, SLC17A6, SCN4B, Kv3.1, GlyRA3, GlyRA1, HCN |
The distribution in GeneGO Processes revealed enrichment in pathways and processes involved in subcellular mechanisms (neurotransmission, ion transport, neuropeptide signaling), as well as in the startle response and the behavioral response to pain.