Fig. 3.

Hippocampal homogenates show a caveolin-dependent reduction in disrupted-in-schizophrenia-1 (DISC1) and synaptic proteins. Hippocampi were isolated from the brains of wild-type (WT) and caveolin-1 knockout (Cav-1 KO) mice (2–3 mo). Homogenates were immunoblotted for Cav-1, DISC1, PSD95, synaptobrevin, neurexin 1, syntaxin 1A, synaptophysin, and GAPDH (A). Quantification of Western blots showed a significant decrease in the protein expression level of DISC1 (B) and other synaptic proteins: PSD95 (C), synaptobrevin (D), neurexin 1 (E), syntaxin 1A (F), and synaptophysin (G). Representative blots are from n = 4 experiments. *P < 0.05; **P < 0.01, WT vs. Cav-1 KO.