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. 2016 Nov 2;117(1):436–444. doi: 10.1152/jn.00481.2016

Fig. 4.

Fig. 4.

Neuron-targeted expression of caveolin-1 (Cav-1) enhances expression of disrupted-in-schizophrenia-1 (DISC1) and synaptic proteins in caveolin-1 knockout (Cav-1 KO) mice hippocampi. Cav-1 KO mice (2 mo) were subjected to stereotactic injection of adeno-associated virus serotype 9 (AAV9) containing SynCav1 or synapsin-red fluorescent protein (SynRFP; as control). Mice were killed 1 mo later and hippocampi were collected and homogenized. Homogenates were immunoblotted for Cav-1, DISC1, PSD95, synaptobrevin, neurexin 1, syntaxin 1A, syntaxin, synaptophysin, and GAPDH (A). Western blot quantification showed that SynCav1 injection restored the Cav-1 expression (B) and significantly increased the expression levels of DISC1 (C) and other synaptic proteins: PSD95 (D), synaptobrevin (E), neurexin 1 (F) and synaptobrevin (H). No significant difference was detected in syntaxin 1A (G). Representative blots are from n = 4 experiments. *P < 0.05; **P < 0.01; ****P < 0.0001, SynCav1 vs. SynRFP.