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. 2016 Dec 21;198(3):1308–1319. doi: 10.4049/jimmunol.1600583

FIGURE 2.

FIGURE 2.

Inhibition of TLR-induced cytokines by BMS-986126 in mice. Mice were dosed orally with either vehicle or the indicated doses of BMS-986126 at 30 min prior to challenge either with 25 mg/kg LTA i.p. (A), 2.5 μg CpG-ODN i.v. (B), or 5 mg/kg gardiquimod i.p (C and D). Ninety minutes after LTA challenge, mice were bled and plasma concentrations of IL-6 were determined by ELISA. Mice were bled 2 and 8 h after CpG challenge, and plasma levels of IFN-α were measured by ELISA. Plasma concentrations of IFN-α (C) and IL-6 (D) were measured at 2 and 8 h after challenge with gardiquimod. Mean and SEM are plotted. Data are from one experiment with eight animals per group. **p < 0.001, ***p < 0.0001, one-way ANOVA with a Dunnett test.