Figure 6.

Arsenite induces a primary hepatocyte phenotype that resists oxidant stress. Arsenic and vehicle alone treated (a) mouse and (b) human primary hepatocytes were exposed to a toxic oxidative stress from 100 μM H₂O₂. Cells from both groups were exposed to H₂O₂ at time = 0 and necrosis was determined using SYTOX Green over 72 h following exposure. Data presented as mean ± SD. ^∗Significantly different from vehicle treated hepatocytes at the designated time point; P < 0.01. ^#Significantly different from 10 uM arsenic treated hepatocytes at the designated time point: P < 0.01.