Table 2.

The association between aspirin use and bone mineral density and fracture risk.

Authors (years)	Characteristics of the subjects	Study design	Findings
			Bone mineral density (BMD)	Fracture risk
Bauer et al. 1996 [30]	7,786 Caucasian women aged 65 years above from the multicentred Study of Osteoporotic Fractures.	BMD measured cross-sectionally and fractures were followed up after 4 years.	↑	↔
Carbone et al. 2003 [32]	2,853 subjects (49.5% women, 50.5% men) aged 73.6 years from the Health, Aging, and Body Composition Study.	BMD measured by DXA and QCT cross-sectionally.	↑	NA
Vestergaard et al. 2012 [31]	2,016 female participants aged 45–58 years from the Danish Osteoporosis Prevention Study.	BMD and fracture of the participant were traced for 10 years.	↔	↔
Vestergaard et al. 2012 [33]	Cases = 124,655 subjects aged 43.44 (SD = 27.39) years. Control = 373,962 subjects aged 43.44 (SD = 27.39) years.	Case-control study	NA	↑