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. 2017 Jan 9;2017:3234906. doi: 10.1155/2017/3234906

Table 2.

Summary of reported cases of acute antibody-mediated rejection following ABO-compatible liver transplantation.

Reference Age/gender Onset of graft dysfunction DSA detection method Type of DSA DSA specificity AMR treatment Clinical outcome
Rostron et al. (2005) [22] 23/F POD 6 Luminex SAB Preformed Bw6 Steroids, MMF, PP, IVIG Alive with functioning graft

Wilson et al. (2006) [23] 36/F 4 years Luminex SAB De novo DR52 Steroids, MMF, PP, IVIG, Rituximab, ATG Alive with functioning graft

Watson et al. (2006) [24] 50/F POD 5 Flow cytometry SAB Preformed B7 Steroids, MMF, PP, IVIG, Rituximab Death

Kamar et al. (2009) [25] 49/F POD 10 Luminex SAB Preformed A2, DR7 Steroids, MMF, PP, Rituximab, OKT3 Death
39/F POD 6 Luminex SAB Preformed A2, A24, B27, DR4 Steroids, PP, Rituximab Alive with functioning graft

Kozlowski et al. (2011) [26] N/A POD 5 Flow cytometry or Luminex SAB Preformed 3 DSA (specificity not provided) Steroids, PP, IVIG, Rituximab Death
N/A POD 7 Preformed A30, A74, B7, B45, DR15, DR51, DQ7 Steroids, PP, IVIG, Rituximab, ATG Death
N/A POD 7 Preformed 4 DSA (specificity not provided) Steroids, PP, IVIG, Rituximab, OKT3 Retransplant, alive

Paterno et al. (2012) [27] 62/F POD 8 Luminex SAB De novo DR13, DR15, DR51, DR52 Steroids, OKT3, ATG, Bortezomib Alive with functioning graft
28/F POD 452 Luminex SAB De novo DQ2, DQ6 Steroids, PP, Rituximab, ATG, Bortezomib Alive with functioning graft
53/F POD 6 Luminex SAB Preformed B51, Cw2, DQ7 Steroids, ATG, Bortezomib Alive with functioning graft

Kheradmand et al. (2014) [28] 43/F POD 1 Luminex SAB Preformed B35, B51, DR4, DR53, DQ8 Steroids, PP, IVIG, Rituximab, ATG Alive with functioning graft

Wozniak et al. (2016) [29] 22 mo/M POD 45 Luminex SAB De novo B44, DQ2 Steroids, MMF, IVIG, Rituximab Alive with functioning graft
3/F POD 13 Luminex SAB N/A A1, DQ5 Steroids, MMF, IVIG Alive with functioning graft
19 mo/F POD 8 Luminex SAB Preformed & de novo Cw7, Cw17, DR4, DR53, DQ8 Steroids, MMF, IVIG, Rituximab Alive with functioning graft
11/M POD 7 Luminex SAB De novo DR53, DQ8 Steroids, MMF, PP, IVIG, ATG, Bortezomib Alive with functioning graft
6 mo/M POD 38 Luminex SAB De novo DQ7, DQ9 Steroids, MMF, PP, IVIG, Rituximab Retransplant, death
3/M POD 7 Luminex SAB Preformed A1, B8, Cw7, DR17, DQ2, DP1 Steroids, MMF, PP, IVIG, Rituximab, Bortezomib, Eculizumab Alive with functioning graft

N/A, not available/information not provided; SAB, single antigen bead-based testing; PP, plasmapheresis; IVIG, intravenous immunoglobulin; ATG, antithymocyte globulin.