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. 2017 Jan 20;7(1):e013810. doi: 10.1136/bmjopen-2016-013810

Figure 6.

Figure 6

Comparison of urinary cytomegalovirus (CMV) screening based on the difference in MRI manifestations in congenital CMV infection. Urine samples were collected from newborns within 0–5 days of birth. (A) Of the 60 newborns, 53 underwent MRI examination. Three newborns had the first MRI scans carried out much later than the other 50 at 7, 10 and 18 months, respectively 50. Thus, three were excluded from the comparison. Of the 50 newborns on whom MRI was performed at less than 5 months of age, 14 (normal) did not have central nervous system (CNS) damage and 36 (abnormal) had CNS damage. No significant difference in the viral load is shown between normal and abnormal (p=0.560). (B) Thirty-one newborns underwent a second MRI scan between 16 months and 20 months of age. Twenty-three newborns (abnormal) were found to have CNS damage during the second scan and eight newborns (normal) had no such abnormalities. A significant difference in the viral load is shown between normal and abnormal (p=0.013). Upper and lower borders of box plots represent the 25th and 75th percentiles and bars represent median viral loads. Upper and lower bars indicate maximum and minimum viral load, respectively.