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Dendritic cells (DCs) activated by Brucella abortus promote TLR7 colocalization with lysosomal-associated membrane protein 1 (LAMP-1)-positive compartments. DCs were stimulated with B. abortus (MOI 100:1) for 24 h. Subsequently, macrophages were fixed and stained to detect host cell and bacterial DNA (blue), TLR7 (red), and LAMP-1 (green) by confocal microscopy. The colocalization between TLR7 and LAMP-1 is highlighted in inserts. NI, non-infected.
