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. 2017 Jan 23;3:16096. doi: 10.1038/cddiscovery.2016.96

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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RIP3 was expressed in most CCA tissues. (a–d) Representative images of IHC using RIP3 antibody in CCA tissues (a–c) and the paired normal liver tissues (d). The left images were shown at ×100 magnification, and the right were corresponding to the left in the red box at ×400 magnification. Yellow represented RIP3, and blue were on behalf of the nucleus. (a) Representative images of negative RIP3 expression in CCA tissues (−). (b) Representative images of low RIP3 expression in CCA tissues (+). (c) Representative images of strong RIP3 expression in CCA tissues (++). (d) Representative images of strong RIP3 expression in CCA-adjacent normal liver tissues (++).