Skip to main content
. 2017 Jan 18;8:14121. doi: 10.1038/ncomms14121

Figure 1. Somatic mutation rates and mutational signatures of NPC tumours identified by WES.

Figure 1

(a) NPC tumours have significantly lower rate of non-synonymous mutations as compared with HPV-positive HNSCC and EBV-positive stomach adenocarcinoma (TCGA, USA). (b) The mutational burden, stratified by the top, mid and low quartile counts per patient, correlated with overall and disease-free survival in NPC patients (N=70 NPC patients with primary tumours). (c) Mutation signatures of 70 primary and 27 recurrent or metastatic NPC cases reveal a primarily C to T transition signature. (d) The top COSMIC cancer mutation signatures in NPC.