TABLE 5.
Amino acid substitutions in CYP51A and CYP51B genes from A. fumigatus itraconazole-resistant mutants
| Mutant strain | Amino acid substitution ina:
|
|
|---|---|---|
| CYP51A | CYP51B | |
| G10-1-50A | G54R, P394L | None |
| G10-2-50A | G54R | None |
| G10-3-50A | G54R, S393S | S177F, P178P |
| G10-1-50B | Y491H | S505P |
| H05-1-10 | L20L | None |
| H05-3-10 | T440A | None |
| H10-1-50A | N22D | None |
| H10-2-50A | M220I | F59L |
| H10-3-50A | M220I | NDb |
a
Amino acids are numbered from the translation start amino acid methionine of CYP51A and CYP51B. The numbers indicate the position at which an amino acid change occurs.
b
ND, not determined.