Table 3.

Association Between Cytochrome P-450 2D6 (CYP2D6) Genotype and Tamoxifen Efficacy Before and After Quantitative Bias Analyses

	Before Quantitative Bias Analysis			Quantitative Bias Analysis Based on 3 Concordance Studies (33, 39, 43)			Quantitative Bias Analysis Based on the Goetz et al. (33) Study Only
	Point Estimate	95% CI	P for Homogeneity	Point Estimate	95% SI	Relative Bias, %	Point Estimate	95% SI	Relative Bias, %
All studies (n = 21)	1.71	1.24, 2.36	<0.001	1.80	1.28, 2.54	−5.4	1.82	1.28, 2.60	−6.8
Studies using nonneoplastic tissue DNA (n = 16)	2.19	1.42, 3.40	<0.001	NA	NA	NA	NA	NA	NA
Studies using tumor-infiltrated tissue DNA (n = 5)	1.09	0.78, 1.53	0.27	1.11	0.69, 1.80	−1.8	1.10	0.65, 1.85	−0.3

Abbreviations: CI, confidence interval; NA, not applicable; SI, simulation interval.