TABLE 1.
Comparison of IDV pharmacokinetic parameters between treatment groups on day 14
| Parameter (n = 12)a | Result for:
|
P value | |||||
|---|---|---|---|---|---|---|---|
| IDV/RTV at 667/100 q12h
|
IDV at 800 q8h
|
Between-treatment comparison of IDV/RTV vs IDV
|
|||||
| Geometric mean | 90% CIb | Geometric mean | 90% CIb | Geometric mean ratio | 90% CIb | ||
| Cmin (nM) | 1,511 | 1,119, 2,039 | 250 | 185, 337 | 6.05 | 3.96, 9.25 | <0.001 |
| Cmax (nM) | 10,428 | 9,209, 11,808 | 10,407 | 9,190, 11,784 | 1.00 | 0.84, 1.19 | 0.985 |
| AUC0-24 (nM · h) | 119,557 | 98,476, 145,150 | 77,034 | 63,451, 93,525 | 1.55 | 1.18, 2.04 | 0.012 |
a
Average natural log (parameter) of dosing intervals was used in an ANOVA model.
b
90% CI for geometric mean are based on the ANOVA model.