TABLE 2.

Composite E_max model parameters

Antifungal and time point (h)	EC50 (multiple of MIC)	EC90 (multiple of MIC)	ECmax (log10 CFU/ ml)	Net inoculum change (log10 CFU/ml)
AMB
1	0.99	1.97	−2.96	−5.28 to 0.25
2	0.80	1.68	−3.65	−5.56 to 0.17
4	0.64	1.78	−4.42	−5.56 to 0.36
8	0.37	1.18	−4.63	−5.56 to 1.00
24	0.70	1.94	−4.55	−5.56 to 2.37
Caspofungin
1	2.02	2.97	−1.45	−5.47 to −0.14
2	1.40	2.34	−1.91	−5.47 to 0.13
4	1.39	2.32	−2.44	−5.47 to −0.50
8	0.48	1.20	−3.06	−5.47 to −0.33
24	1.05	1.94	−3.62	−5.47 to 0.60
FLC
4	1.34	2.28	0.33	−0.04 to 1.02
8	1.18	2.10	0.41	0.03 to 2.08
24	1.26	2.18	0.59	0.06 to 2.50
VRC
4	0.99	1.99	0.31	−0.20 to 1.03
8	0.74	1.60	0.30	−0.34 to 2.09
24	0.88	1.77	0.47	−0.09 to 2.89