TABLE 1.

Plasma indinavir PK parameters over 12 h for three different doses^a

Patient or parameter	Cmax (ng/ml)			Cmin						AUC0-12b (ng · h/ml)
				C0h			C12h
	800/100c	600/100	400/100	800/100	600/100	400/100	800/100	600/100	400/100	800/100	600/100	400/100
1	7,965	4,348	2,375	1,317	295	213	447	212	170	45,467	22,589	12,726
2	7,336	4,881	2,986	1,157	583	336	501	283	105	43,745	26,464	14,237
3	7,596	4,909	3,120	510	287	289	172	108	124	35,691	20,842	14,515
4	8,149	7,789	2,939	820	228	404	380	199	135	47,944	26,249	16,234
5	17,316	11,696	5,863	1,565	1,242	370	964	357	303	85,640	52,516	25,954
Median	7,965	4,909	2,986	1,157	295	336	447	212	135	45,467	26,249	14,515
Mean	9,672	6,725	3,457	1,074	527	322	493	232	167	51,697	29,732	16,733
SD	4,285	3,090	1,375	415	423	74	291	94	79	19,522	12,961	5,303

^aP values for comparisons of parameters were all less than 0.01.

^bAUC, area under the indinavir pharmacokinetic curve.

^cDoses (given twice daily) are given in milligrams of indinavir/milligrams of ritonavir.