TABLE 3.

Time-kill study results^a

Drug and MIC	No. of strains for which the levels of killingb were as indicated at the following times:
	3 h			6 h			12 h			24 h
	−1	−2	−3	−1	−2	−3	−1	−2	−3	−1	−2	−3
GW 773546
4× MIC	10	2	0	9	6	0	12	9	6	11	11	8
2× MIC	6	2	0	9	4	0	11	8	5	11	11	8
MIC	5	2	0	8	3	0	9	5	2	11	9	5
GW 708408
4× MIC	10	2	0	11	5	0	12	9	5	11	11	9
2× MIC	7	2	0	8	3	0	11	9	5	11	11	7
MIC	5	2	0	7	2	0	11	5	2	7	6	4
Telithromycin
4× MIC	9	4	1	10	7	3	12	11	7	12	12	10
2× MIC	8	4	1	10	5	1	12	11	7	12	12	8
MIC	6	2	1	8	4	0	12	8	3	11	8	4
Erythromycin
4× MIC	3	0	0	3	1	1	6	5	2	6	6	4
2× MIC	3	0	0	3	1	1	5	4	2	6	6	4
MIC	3	0	0	3	0	0	5	2	1	6	3	2
Azithromycin
4× MIC	3	0	0	4	1	1	6	6	2	6	6	5
2× MIC	3	0	0	3	1	0	5	4	2	6	5	4
MIC	3	0	0	3	1	0	5	3	2	6	5	4
Clarithromycin
4× MIC	3	1	0	3	2	0	6	5	4	6	6	6
2× MIC	2	1	0	3	2	0	6	5	3	6	6	6
MIC	2	1	0	3	1	0	6	3	3	6	5	3
Clindamycin
4× MIC	7	1	0	6	2	0	9	5	1	9	9	8
2× MIC	3	1	0	4	1	0	8	4	1	9	9	7
MIC	1	1	0	3	0	0	7	2	1	9	6	2

^aOnly GW 773546, GW 708408, and telithromycin were tested with the three strains with erm(B).

^b−1, 90% killing; −2, 99% killing; −3, 99.9% killing.