TABLE 6.
PAEs of GW 773546, GW 708408, and telithromycin against nine S. pneumoniae strains
| Drug | Erythromycin-sensitive strainsa
|
Erythromycin-resistant strains [erm(B)]a
|
Erythromycin-resistant strains [mef(E)]a
|
|||
|---|---|---|---|---|---|---|
| MIC range (μg/ml) | PAEb | MIC range (μg/ml) | PAE | MIC range (μg/ml) | PAE | |
| GW 773546 | 0.0005-0.004 | 6.4 (4.0-8.6) | 0.004-0.06 | 4.5 (3.6-5.8) | 0.016-0.06 | 6.1 (4.8-7.0) |
| GW 708408 | 0.001-0.008 | 5.6 (3.1-7.3) | 0.008-0.12 | 3.5 (2.8-4.2) | 0.06-0.12 | 5.8 (5.3-6.2) |
| Telithromycin | 0.004-0.016 | 6.5 (3.6-9.2) | 0.03-0.06 | 4.1 (2.4-5.9) | 0.06-0.12 | 8.4 (6.4-9.8) |
a
Three strains were analyzed.
b
The values are the mean (range) PAE (in hours). The PAE was induced by 1 h of exposure to 10 times the MIC.