FIG. 2.

PTX3 reduces lung pathology in mice with invasive aspergillosis. Periodic acid-Schiff-stained sections were prepared from lungs of bone marrow-transplanted mice infected with Aspergillus conidia either untreated (A) or treated (B) with 1 mg of PTX3/kg intraperitoneally from the day of the infection and continuing for an additional 5 days. Numerous Aspergillus hyphae (arrows) infiltrating the lung parenchyma, with extensive parenchymal destruction, severe signs of bronchial wall damage, and necrosis and scarce inflammatory cell recruitment are observed in the lungs of untreated mice (at 3 days after infection), as opposed to what is observed for PTX3-treated mice, whose lungs were characterized by healing infiltrates of inflammatory cells with no evidence of parenchymal destruction and fungal growth (at 6 days after infection). Magnification, ×100 in panels A and B; ×400 in the insets.