TABLE 1.
Pharmacokinetic parameters for plasma, adipose tissue, and skeletal muscle following oral administration of 320 mg of gemifloxacin
| Compartment (no. of samples) | AUC0-10 for tissue/AUC0-10 for free plasma | AUC0-10 (mg · h/liter) | AUC0-24 (mg · h/liter) | Cmax (mg/liter) | Tmax (h) | t1/2β (h) | CL(F) (liters/h) | V(F) (liters) |
|---|---|---|---|---|---|---|---|---|
| Plasma, total (12) | 4.0 ± 1.2 | 5.3 ± 1.6 | 1.2 ± 0.4 | 1.3 ± 0.6 | 5.0 ± 0.8 | 49 ± 22 | 334 ± 118 | |
| Plasma, free (12) | 1.6 ± 0.5 | 2.2 ± 0.6 | 0.5 ± 0.2 | 1.3 ± 0.6 | 5.0 ± 0.8 | NDa | ND | |
| Muscle (12) | 1.7 ± 0.7 | 2.6 ± 1.2b | 4.0 ± 1.9 | 0.5 ± 0.2 | 2.1 ± 0.4 | 5.7 ± 1.6 | ND | ND |
| Adipose tissue (11) | 2.4 ± 1.0 | 3.7 ± 2.1b | 5.4 ± 3.0 | 0.8 ± 0.5 | 1.8 ± 0.4 | 5.4 ± 1.1 | ND | ND |
a
ND, not determined.
b
P < 0.05 compared to free plasma value.