TABLE 2.
Comparison of itraconazole MICs against C. glabrata isolates by the NCCLS M27-A2 (48 h), Sensititre YeastOne (24 h), and Etest (48 h) methods at different pHs
| Isolate | MIC (μg/ml)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| pH 6.0
|
pH 7.0
|
pH 7.4
|
|||||||
| NCCLS | SYO | ETa | NCCLS | SYO | ET | NCCLS | SYO | ET | |
| 2 | 1 | 2 | >32 | 2 | 4 | 6 | 0.125 | 1 | 0.75 |
| J | 1 | >4 | >32 | 1 | 4 | 8 | 0.125 | 2 | 0.75 |
| P | 1 | >4 | >32 | 2 | >4 | 4 | 0.125 | >4 | 3 |
| Q | 2 | >4 | >32 | 1 | >4 | 4 | 0.125 | >4 | 2 |
| R | 2 | >4 | >32 | 1 | >4 | 4 | 0.125 | >4 | 2 |
| Z-M | 4 | >4 | >32 | 0.5 | >4 | >32 | 0.5 | >4 | 4 |
| Z-V | 4 | >4 | >32 | 4 | >4 | 8 | 1 | >4 | 2 |
| Z-Y | 4 | >4 | >32 | 4 | >4 | 16 | 0.5 | >4 | 1 |
| Z-Z | 4 | >4 | >32 | 4 | >4 | 8 | 0.5 | >4 | 4 |
| Z-zAA | 4 | >4 | >32 | 4 | 4 | 16 | 0.5 | 2 | 1.5 |
| Z-zAC | 4 | >4 | >32 | 1 | 4 | >32 | 1 | 0.5 | >32 |
| Z-zAD | 1 | 2 | >32 | 1 | 2 | 32 | 1 | 0.5 | 8 |
| Z-zAF | 2 | 1 | >32 | 1 | 1 | 6 | 0.5 | 0.5 | 2 |
| Z-zAN | 0.06 | 0.125 | 0.016 | 0.125 | 0.25 | 0.016 | 0.06 | 0.125 | 0.016 |
| Z-zAS | >4 | >4 | >32 | >4 | 4 | >32 | >4 | >4 | >32 |
a
ET, Etest.