TABLE 3.
Comparison of voriconazole MICs against C. glabrata isolates by the NCCLS M27-A2 (48 h), Sensititre YeastOne (24 h), and Etest (48 h) methods at different pHs
Isolate | MIC (μg/ml)
|
||||||||
---|---|---|---|---|---|---|---|---|---|
pH 6.0
|
pH 7.0
|
pH 7.4
|
|||||||
NCCLS | SYO | ETa | NCCLS | SYO | ET | NCCLS | SYO | ET | |
2 | 0.25 | 0.5 | 0.75 | 0.25 | 0.25 | 0.5 | 0.03 | 0.03 | 0.25 |
J | 0.5 | 2 | 1 | 0.125 | 0.25 | 0.75 | 0.03 | 0.125 | 0.094 |
P | 0.5 | 2 | 1.5 | 0.125 | 0.25 | 1 | 0.06 | 0.125 | 0.38 |
Q | 1 | 2 | 2 | 0.25 | 0.5 | 0.75 | 0.06 | 0.25 | 0.5 |
R | 1 | 2 | 1.5 | 0.25 | 0.5 | 0.75 | 0.06 | 0.25 | 0.38 |
Z-M | 2 | 2 | 1.5 | 1 | 0.5 | 1 | 0.5 | 0.125 | 0.25 |
Z-V | 2 | 2 | 1 | 2 | 0.5 | 0.75 | 0.5 | 0.25 | 0.38 |
Z-Y | 2 | 2 | 1.5 | 1 | 0.5 | 1 | 0.25 | 0.5 | 0.38 |
Z-Z | 2 | 2 | 2 | 1 | 0.5 | 1 | 0.25 | 0.25 | 0.38 |
Z-zAA | 2 | 2 | 1.5 | 1 | 0.25 | 1 | 0.25 | 0.125 | 0.19 |
Z-zAC | 4 | 4 | 4 | 2 | 0.25 | 2 | 1 | 0.125 | 1.5 |
Z-zAD | 1 | 1 | 1.5 | 0.5 | 0.125 | 0.38 | 0.5 | 0.06 | 0.19 |
Z-zAF | 2 | 1 | 1 | 0.5 | 0.25 | 0.38 | 0.25 | 0.125 | 0.094 |
Z-zAN | 0.015 | 0.06 | 0.006 | 0.015 | 0.015 | 0.008 | 0.015 | 0.008 | 0.006 |
Z-zAS | >4 | >4 | >32 | 4 | 4 | 16 | 4 | 2 | 4 |
ET, Etest.