FIG. 1.

Structure of pentamidine and general structure of the piperazine-linked bisbenzamidines. (A) Pentamidine has two benzamidine moieties linked by a pentyldioxy chain. (B) 1,4-piperazinediyl parent compound. Alkyl or cycloalkyl groups were introduced on one of the nitrogen atoms of the amidine moieties (R).