Individual concentration-time profiles for ARM (A) and its metabolite DHA (B) after the first i.m. dose of 10.7 μmol (3.2 mg) of ARM/kg to 10 patients with severe P. falciparum infection. For ARM, two patients had samples collected to 10 h, three patients had samples collected to 12 h, and five patients had samples collected to 24 h. For DHA, two patients had samples collected to 10 h, three patients had samples collected to 12 h, and five patients had samples collected to 24 h. In five of the profiles some of the concentration-time points shown were undetected (zero) or below the assay limit of quantitation.