TABLE 3.
Effect of increasing concentrations of MPA and RBV on the antiviral activity of DAPD and DXG against virus containing the K65R/Q151M mutations (PBMC)
| Initial treatment [EC50 (fold Δ)]a | Addition
|
||||||
|---|---|---|---|---|---|---|---|
| Control | 0.05 μM MPA | 0.1 μM MPA | 0.2 μM MPA | 2.5 μM RBV | 5 μM RBV | 10 μM RBV | |
| DAPD | >250 (1) | >250 (1) | 140 ± 30 (>1.8) | 2.9 ± 1.3 (>86) | 225 ± 7 (1) | 120 ± 20 (>2) | 22 ± 2 (>11) |
| DXG | 30 ± 9 (1) | 33 ± 6 (1) | 2 ± 0.7 (15) | <0.2 (>150) | 7.8 ± 0.8 (4) | 3.7 ± 0.4 (8) | 0.22 ± 0.01 (136) |
a
EC50 values in micromolars data represent the means of two experiments ± standard deviations.