TABLE 4.
Effects of DAPD, DXG, MPA, and RBV on mitochondrial DNAa
| Compound | mtDNAa at a concentration (μM) of:
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.1 | 0.25 | 0.5 | 1 | 5 | 10 | 20 | 25 | 40 | 50 | 80 | |
| DAPD | 94 ± 8 | 92 ± 3 | 72 ± 5 | 67 ± 3 | 46 ± 1 | ||||||
| DAPD+MPAb | 74 ± 18 | 96 ± 8 | 97 ± 4 | 78 ± 4 | 53 ± 4 | ||||||
| DAPD+RBVb | 73 ± 1 | 79 ± 6 | 63 ± 13 | 29 ± 11 | 19 ± 6 | ||||||
| DXG | 95 ± 9 | 79 ± 6 | 82 ± 8 | 79 ± 8 | 72 ± 19 | ||||||
| DXG+MPA | 126 ± 16 | 122 ± 8 | 96 ± 9 | 96 ± 11 | 98 ± 3 | ||||||
| DXG+RBV | 83 ± 5 | 69 ± 5 | 69 ± 11 | 61 ± 16 | 55 ± 13 | ||||||
| ddCc | 99 ± 5 | 30 ± 1 | 15 ± 1 | 11 ± 1 | 12 ± 1 | ||||||
| RBV | 93 ± 9 | 102 ± 11 | 88 ± 9 | 84 ± 12 | 80 ± 5 | ||||||
| MPA | 75 ± 15 | 72 ± 12 | 51 ± 16 | 44 ± 23 | 39 ± 20 | ||||||
a
Data are expressed as percent mtDNA ± standard deviations from the means of three experiments.
b
MPA, 0.25 μM; RBV, 20 μM.
c
ddC, dideoxycytidine.