Skip to main content
. 2004 Nov;24(22):9958–9967. doi: 10.1128/MCB.24.22.9958-9967.2004

FIG. 7.

FIG. 7.

Effects of increased NAD+ or TDP on cellular responses to ionizing radiation. (A) MCF7 cells were treated to increase NAD+ or TDP and then irradiated (IR). After 5 days, chromosome aneuploidy in 100 metaphase spreads per sample was analyzed. Bars indicate the numbers of cells displaying aneuploidy greater than that displayed by the average control cell. NAm, niacinamide; Cont, control. (B) Murine thymocytes from wild-type (p53+/+) or p53 knockout (p53−/−) mice were explanted and incubated to increase NAD+ or TDP and then irradiated. Dex, dexamethasone treatment. (C) Mice were treated to increase NAD+ and then irradiated. Thymocytes were collected after 18 h.