TABLE 2.
Type I survivors tend to have higher frequencies of His+ prototroph formation
| Genotype (n) | Survivor type | His+ frequency (10−9)a
|
Y′ his3A1 DNAd
|
Y′ DNAbd
|
|||
|---|---|---|---|---|---|---|---|
| Range | Median | Range | Median | Range | Median | ||
| JC3840/1 (4) | I | 35-290 | 170 | 0.96-22 | 1.8 | 15-84 | 26 |
| JC3840/1 (12) | II | 0.42-110 | 11 | 0.33-6.3 | 1.0 | 0.27-10 | 1.5 |
| JC3723:X1 (6) | I | 45-7,200 | 635 | NDc-16 | 1.6 | 11-32 | 26 |
a
His+ frequencies reported in Fig. 2 for 20°C assays.
b
Combined signal for Y′-L and Y′-S.
c
ND, not detected. Y′his3A1 was no longer detected in one JC3723:X1 survivor after it was assayed for His+ prototroph formation and DNA was extracted.
d
Copy number relative to that for telomerase-positive strains.