FIG. 2.

Phenotypic alterations of HtrA2/Omi knockout mice. (A) Body weights of wild-type (HtrA2/Omi^+/+), heterozygous (HtrA2/Omi^+/−), and knockout (HtrA2/Omi^−/−) littermates. Data shown are means ± standard deviations of results for at least six animals for each point. (B) Appearance of day 30 HtrA2/Omi knockout and littermate control wild-type animals. (C) HtrA2/Omi knockout mice show a general decrease in organ size. This decrease is more dramatic with the spleen, thymus, and heart; the brain is approximately 75% of the weight of wild-type control brains.