Sensorimotor tests on knockout mice. HtrA2+/+, HtrA2+/−, and HtrA2−/− mice were placed on a 60o-inclined platform. (A) Percentages of mice that climbed to the top of the platform. Wild-type (+/+; n = 8); heterozygote (+/−; n = 20), and knockout (−/−; n = 16) littermates were compared. (B) Average elapsed times for mice to climb to the top of the platform. Data are means ± standard deviations of results from a minimum of eight trials. (C) Percentages of mice that remained on the platform for the full 60-s trial period. Wild-type (+/+; n = 8), heterozygote (+/−; n = 20), and knockout (−/−; n = 16) littermates were compared.