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. 2004 Nov;24(22):9848–9862. doi: 10.1128/MCB.24.22.9848-9862.2004

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Copyright © 2004, American Society for Microbiology

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FIG. 4. — Morphological features of localized striatal degeneration in HtrA2/Omi knockout mice. (A) Hematoxylin and eosin staining showing focal loss of neurons and occasional ballooning in the striata of HtrA2/Omi knockout animals (right) compared to controls (^+/+) (left). (B) GFAP immunohistochemistry revealing the reaction of astrocytes in knockout animals (right). (C) MAP2 immunohistochemistry revealing the loss of this protein in sections from knockout animals (right). (D) Diagram of a mouse brain in sagital orientation indicating the area of striatal degeneration (red box) in the striatum. (E and F) Density of NeuN-positive neurons in the striata (Str) of wild-type and HtrA2/Omi knockout mice scored for both the whole striatum (total basal ganglia) and the area where localized degeneration was observed (posterior portion of the basal ganglia). Analysis was performed with both P₂₀ and P₃₀ animals. (G and H) Average optical density of TH staining in both the total basal ganglia and the area where localized degeneration was observed (posterior portion of the basal ganglia). (I) Average number of TH-positive neurons in the substantia nigra pars compacta of wild-type and HtrA2/Omi knockout animals.

FIG. 4. — Morphological features of localized striatal degeneration in HtrA2/Omi knockout mice. (A) Hematoxylin and eosin staining showing focal loss of neurons and occasional ballooning in the striata of HtrA2/Omi knockout animals (right) compared to controls (^+/+) (left). (B) GFAP immunohistochemistry revealing the reaction of astrocytes in knockout animals (right). (C) MAP2 immunohistochemistry revealing the loss of this protein in sections from knockout animals (right). (D) Diagram of a mouse brain in sagital orientation indicating the area of striatal degeneration (red box) in the striatum. (E and F) Density of NeuN-positive neurons in the striata (Str) of wild-type and HtrA2/Omi knockout mice scored for both the whole striatum (total basal ganglia) and the area where localized degeneration was observed (posterior portion of the basal ganglia). Analysis was performed with both P₂₀ and P₃₀ animals. (G and H) Average optical density of TH staining in both the total basal ganglia and the area where localized degeneration was observed (posterior portion of the basal ganglia). (I) Average number of TH-positive neurons in the substantia nigra pars compacta of wild-type and HtrA2/Omi knockout animals.