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. 2004 Nov 1;18(21):2652–2662. doi: 10.1101/gad.1241204

Figure 3.

Figure 3.

Lrp1 is required for UV-induced RNA degradation. (A) Upon UV-irradiation, wild-type cells show destabilization of the most stable mRNA subpopulation (black). The stability of each transcript in nonirradiated cells is plotted against its stability after UV irradiation, as the log ratio of abundance after 45-min degradation to original abundance. (B) Transcripts in Δlrp1 cells (gray) do not exhibit the UV-induced degradation pattern of wild-type cells. (C) Transcripts in Δrrp6 cells show the same UV-induced degradation phenotype as do wild-type cells. (D) The distribution of mRNAs over the mRNA stability range of UV-irradiated wild-type cells is shown for mRNAs that exhibit Lrp1-dependent degradation in UV-irradiated cells (black) and increased (dark gray) and unaltered (light gray) degradation in UV-irradiated wild-type cells.