Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jan 3;114(3):498–503. doi: 10.1073/pnas.1617414114

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 2. — Universal loss of cells with the Mdm2^+/−Mdm4^+/− genotype in the developing embryos. (A) A schematic diagram of generating the mosaic embryos. BW, body weight. (B) Whole-mount X-Gal staining of the embryos 36 h after tamoxifen injection (E6.5). Embryonic tissues were marked by dotted lines. (Scale bars, 1 mm.) (C) X-Gal staining of heart, kidney, liver, and lung from E19.5 UBC-creERT2; Rosa-lacZ; Mdm2^flox/+ (M2^f/+) and UBC-creERT2; Rosa-lacZ; M/M embryos. (Scale bars, 100 μm.) (D) QRT-PCR analysis of LacZ levels from tissues of E19.5 UBC-creERT2; Rosa-lacZ; Mdm2^flox/+ (M2^f/+) and UBC-creERT2; Rosa-lacZ; M/M embryos (n ≥ 3). Data are presented as mean ± SD. **P ≤ 0.01; ***P ≤ 0.001 (two-tailed t test).