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Matrix cross-linking alters angiogenic sprouting into collagen gels in the chick CAM model. Angiogenic sprouting (arrowheads) into 1.5-mg/mL collagen gels glycated with 0 or 100 mM ribose were imaged with confocal microscopy (A), and the vessel density per gel was quantified (B). (Scale bar, 200 μm.) Data are presented as mean + SEM; *P < 0.05.
