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. 2017 Jan 3;114(3):E416–E425. doi: 10.1073/pnas.1612383114

Fig. 7.

Fig. 7.

(A) INa traces recorded in HL-1 cells transfected or not with WT or p.R311C Tbx20 by applying the pulse protocol (Top). (B and C) Current density–voltage relationships (B) and steady-state inactivation (C) for INa recorded in the three experimental groups. (D and E) Superimposed INa traces (D) recorded in HL-1 cells transfected or not with WT or p.R311C Tbx20 by applying 500-ms pulses from −120 to −20 mV and bar graph (E) showing the mean INaL recorded at 500 ms. (F and G) Normalized luciferase activity in HL-1 cells expressing the pLightSwitch_Prom vector carrying the human SCN5A (F) or SCN2B (G) promoters cotransfected or not with WT or p.R311C Tbx20. Each point/bar represents the mean ± SEM of n cells or N dishes of cells in each group. **P < 0.01 vs. Tbx20 (-).