Table S4.

Presence of the Tbx20 binding site in human and mouse promoter sequences of genes encoding ion-channel subunits and transcription factors relevant to human cardiac repolarization

Gene	Human		Mouse
	Transcript, accession no.	Tbx20 binding site in proximal promoter	Transcript, accession no.	Tbx20 binding site in proximal promoter
ABCC9	XM_005253288.2	No	NM_021042	No
CACNA1C	XM_011521022.1	No	NM_009781	−1884
CACNA1G	NM_001256325.1	No	NM_009783.3	No
CACNA1H	NM_021098.2	No	NM_021415.4	No
CACNA2D1	NM_000722.3	No	NM_009784	No
CACNB2	NM_201590.2	No	NM_023116	No
GATA4	NM_002052.3	No	NM_008092.3	No
GATA5	NM_080473.4	No	NM_008093.2	No
HCN1	NM_021072.3	No	NM_010408	No
HCN2	NM_00194.3	No	NM_008226	−2037
HCN3	NM_020897.2	No	NM_008227.1	No
HCN4	NM_005477.2	No	NM_001081192	No
IRX1	NM_024337.3	No	NM_010573.2	No
IRX4	NM_001278632.1	No	NM_018885.2	No
IRX5	NM_005853.5	No	NM_018826.2	No
KCNE1	NM_000219.5	−544	NM_008424.3	−865/−790
KCNE2	NM_172201.1	−467	NM_134110.3	No
KCNE3	NM_005472.4	No	NM_001190869.1	No
KCNH2	NM_000238.3	+161	NM_013569.2	+88
KCNJ11	NM_001166290.1	−678	NM_001204411.1	No
KCNJ12	NM_021012.4	No	NM_010603.6	−2546
KCNJ2	NM_000891.2	No	NM_008425	No
KCNJ3	NM_002239.3	No	NM_008426	No
KCNJ4	NM_152868.2	No	NM_008427.4	−1984
KCNJ5	NM_000890.3	No	NM_010605.4	−2721
KCNJ8	NM_004982.3	−572	NM_008428	−783
KCNN3	NM_002249.5	−550	NM_080466.2	−1259
KCNQ1	NM_000218.2	No	NM_008434	−1992/−2474
MEF2C	NM_001193350.1	No	NM_001170537.1	No
NKX2.5	NM_004387.3	No	NM_008700.2	No
SCN1B	NM_001037.4	No	NM_011322	No
SCN2B	NM_004588.4	−314	NM_001014761	−576
SCN3B	XM_011542897.1	No	NM_178227	−496
SCN4B	NM_001142348.1	No	NM_001013390	−2999/−1149
SCN5A	NM_001160161.1	No	NM_021544.4	No
TBX5	NM_181486.2	No	NM_011537.3	No
TBX20	NM_001077653.2	No	NM_194263.2	No

Mouse and human promoter sequences were obtained from epd.vital-it.ch and switchgeargenomics.com/products/promoter-reporter-collection, respectively. Human sequences include positions ∼−800 to +200, whereas mouse sequences include positions ∼−3000 to +200. Positions were numbered with respect to the transcription start site (+1). Rat KCNJ2 promoter sequence (XM_006247567.2) does not exhibit the Tbx20 consensus binding site.