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Proposed model for Dyn1-dependent endocytosis of TRAIL–DR complexes to suppress apoptotic signaling. TRAIL-induced DR activation leads to caspase-8 cleavage/activation, which in turn activates RyR-mediated Ca2+ release from ER stores and calcineurin activation to dephosphorylate and activate Dyn1. The selective regulation of TRAIL–DR endocytosis suppresses TRAIL-mediated apoptosis in cancer cells.
