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. 2017 Jan 3;114(3):504–509. doi: 10.1073/pnas.1615072114

Fig. S1.

Fig. S1.

Dynamin isoforms differentially regulate TRAIL-mediated cell killing. TRAIL effects on cell viability in control, AP2, CHC, Dyn1, and Dyn2 siRNA-treated cells. (A) MDA-MB-231 and (B) A549 cells were incubated with the indicated concentrations of TRAIL and assayed for cell viability. TRAIL-resistant A549 were incubated with the indicated concentrations of a DR4-specific variant (TRAIL 4C7) (1–1,000 ng/mL) (C), or of a DR5-specific variant (TRAIL D269H/E195R) (D), and then assayed for cell viability. Reduction in cell viability (%) was calculated relative to control wells containing no ligand. All of the results are mean values ± SD (n = 3). Two-tailed Student’s t tests were used to assess statistical significance. *P < 0.05, ***P < 0.0005.