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. 2017 Jan 3;114(3):504–509. doi: 10.1073/pnas.1615072114

Fig. S2.

Fig. S2.

Down-regulation of CME components increased surface expression of DR. siRNA-mediated knockdown of Dyn1 and Dyn2 in A549 cells. (A) Immunoblots probed for Dyn1 and Dyn2. (B) Quantification of Dyn2 and Dyn1 expression differences in siRNA knockdown cells. Normalized levels of surface bound FLAG-tag TRAIL (relative to control) in MDA-MB-231 (C) and A549 cells (D) treated with Dyn1, Dyn2, AP2, and CHC siRNA. The results are mean values ± SD (n = 3). Two-tailed Student’s t tests were used to assess statistical significance. *P < 0.05, ***P < 0.0005.