Table S1.
Crystallographic statistics
| Variables | Compound 1 | Compound 2 | Compound 3 | Compound 4 | Compound 5 | Compound 6 | Compound 7 |
| PDB ID Code | 5KMI | 5KMJ | 5KMK | 5KML | 5KMM | 5KMN | 5KMO |
| Wavelength (Å) | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Resolution range (Å) | 45.09–1.87 (1.937–1.87) | 22.55–2.04 (2.118–2.045) | 45.3–2.24 (2.325–2.245) | 22.89–2.01 (2.086–2.014) | 44.22–2.12 (2.196–2.12) | 44.3–2.14 (2.217–2.14) | 44.87–2.67 (2.768–2.672) |
| Space group | P3112 | P3112 | P3112 | P3112 | P3112 | P3112 | P3112 |
| Unit cell | a = 52.07 | a = 52.27 | a = 52.31 | a = 51.92 | a = 52.06 | a = 52.15 | a = 51.81 |
| b = 52.07 | b = 52.27 | b = 52.31 | b = 51.92 | b = 52.06 | b = 52.15 | b = 51.81 | |
| c = 227.19 | c = 225.525 | c = 224.89 | c = 230.96 | c = 226.03 | c = 228.53 | c = 229.55 | |
| α = β = 90 γ = 120 | α = β = 90 γ = 120 | α = β = 90 γ = 120 | α = β = 90 γ = 120 | α = β = 90 γ = 120 | α = β = 90 γ = 120 | α = β = 90 γ = 120 | |
| Total reflections | 294,696 (29,961) | 226,772 (22,577) | 170.646 (17,554) | 238,335 (22,879) | 196,299 (16,580) | 200,235 (20,050) | 101,105 (10,541) |
| Unique reflections | 29,752 (2,939) | 22,857 (2,257) | 17,308 (1,691) | 24,144 (2,394) | 20,453 (2,026) | 20,182 (1,987) | 10,402 (1,026) |
| Multiplicity | 9.9 (10.2) | 9.9 (10.0) | 9.9 (10.4) | 9.9 (9.6) | 9.6 (8.2) | 9.9 (10.1) | 9.7 (10.3) |
| Completeness (%) | 99.98 (100.00) | 99.98 (100.00) | 99.75 (99.59) | 100.00 (100.00) | 99.98 (100.00) | 100.00 (100.00) | 99.98 (100.00) |
| Mean I/σ(I) | 25.34 (4.19) | 19.56 (4.69) | 28.98 (4.72) | 27.06 (4.50) | 30.36 (3.83) | 11.30 (3.89) | 13.32 (4.98) |
| Wilson B-factor | 30.51 | 32.4 | 48.17 | 32.58 | 42.23 | 31.02 | 37.62 |
| Rmerge | 0.054 (0.59) | 0.077 (0.554) | 0.04716 (0.5275) | 0.05978 (0.5388) | 0.0451 (0.5801) | 0.145 (0.565) | 0.1556 (0.5287) |
| Rwork | 20.9 (27.6) | 19.2 (23.9) | 22.8 (31.4) | 20.3 (26.6) | 21.7 (29.9) | 19.4 (24.4) | 20.3 (25.6) |
| Rfree | 25.4 (30.3) | 23.1 (27.9) | 28.9 (34.3) | 24.0 (32.1) | 27.0 (35.1) | 22.6 (27.0) | 25.9 (30.0) |
| No. of nonhydrogen atoms | 2,511 | 2,488 | 2,460 | 2,431 | 2,431 | 2,449 | 2,319 |
| Macromolecules | 2,373 | 2,372 | 2,401 | 2,338 | 2,361 | 2,330 | 2,274 |
| Ligands | 30 | 25 | 28 | 30 | 27 | 31 | 23 |
| Water | 108 | 91 | 31 | 63 | 43 | 88 | 22 |
| Protein residues | 300 | 300 | 304 | 297 | 301 | 297 | 291 |
| RMS (bonds) | 0.014 | 0.014 | 0.014 | 0.013 | 0.014 | 0.014 | 0.014 |
| RMS (angles) | 1.65 | 1.67 | 1.77 | 1.69 | 1.78 | 1.69 | 1.86 |
| Ramachandran favored (%) | 98 | 97 | 94 | 99 | 96 | 99 | 94 |
| Ramachandran outliers (%) | 0 | 0 | 1 | 0.35 | 0 | 0.35 | 0.71 |
| Average B-factor | 38.2 | 39 | 57.8 | 40.2 | 51.9 | 37.7 | 40.6 |
| Macromolecules | 38.3 | 39.2 | 58 | 40.4 | 52.2 | 37.9 | 40.8 |
| Ligands | 32 | 28.9 | 52.2 | 35.5 | 44.8 | 25.9 | 27.6 |
| Solvent | 37.8 | 37.1 | 40.5 | 33.2 | 39.5 | 35.4 | 31.1 |
Numbers in parentheses represent statistics from the highest resolution bin.