Fig. 2.

CD74 has a specific immune oriented role as a transcription factor. CLL cells from four samples were activated with anti-CD74 activating Ab for 1 h. Following activation, the cells were fixed, and ChIP-seq was conducted using CD74 Ab. GREAT analysis of the high confidence peaks was performed. The local directed acyclic graph is shown. The numbers relates to the binomial fold-change. (A) The biological processes controlled by CD74 identified by Gene Ontology (GO) analysis. (B) Enriched terms in disease ontology showing that CD74 specifically binds in the proximity of genes that are involved in diseases relating to lymphocytes, specifically in different types of lymphomas. dsDNA, double-stranded DNA.